Add script to detect by threshold and script to get mouse pos.

config.json

 {
-  "outputloc": [100, 100],
+  "outputloc": [1480, 800],
   "outputtext": "test",
   "grabs": [
-    [100,100,20],
-    [200,200,20],
-    [300,300,20]
+    [1335, 870, 20],
+    [1260, 210, 20],
+    [1370, 360, 20],
+    [820, 315, 20],
+    [1301, 501, 20],
+    [525, 187, 20],
+    [861, 510, 20],
+    [434, 826, 20]
   ]
 }

detect-thresh.py

+#!/usr/bin/env python2
+from PIL import ImageChops
+from pyscreenshot import grab
+from time import sleep
+import json
+import pyautogui
+
+# Load config
+with open('config.json') as c:
+  conf = json.load(c)
+
+# Calculate box coordinates from x, y and radius
+boxes = []
+for g in conf['grabs']:
+  boxes.append( (g[0]-g[2], g[1]-g[2], g[0]+g[2], g[1]+g[2]) )
+
+# Grab starting images to compare
+source = []
+for i, b in enumerate(boxes):
+  source.append(grab(bbox=b).convert('RGB'))
+  #source[i].show() # Useful for debugging box locations
+
+# Main loop
+while True:
+  dest   = []
+
+  sleep(1)
+  for i, b in enumerate(boxes):
+    dest.append(grab(bbox=b).convert('RGB'))
+    #dest.append(ImageChops.difference(tmp, source[i]))
+    #diff.append(dest[i].getbbox())
+
+  # Write output if diffs are detected
+  for i, d in enumerate(dest):
+    diff = ImageChops.difference(source[i], dest[i])
+    hist = diff.histogram()
+    dico = len(filter(lambda a: a != 0, hist))
+
+    print str(i) + ":" + str(dico)
+    if dico > 100:
+      pyautogui.click(conf['outputloc'][0], conf['outputloc'][1])
+      pyautogui.typewrite(conf['outputtext'])
+      print 'I have done the deed!'
+      exit(0)
+

getmouse.py

+#!/usr/bin/env python2
+import pyautogui
+
+print pyautogui.position()

grabtest.py

@@ -3,8 +3,8 @@
 
 from pyscreenshot import grab
 
-loc = [700, 200]
-
-im = grab(bbox=(loc[0]-50, loc[1]-50, loc[0]+50, loc[1]+50))
+loc = [434, 826]
+r   = 20
+im = grab(bbox=(loc[0]-r, loc[1]-r, loc[0]+r, loc[1]+r))
 im.show()